Hi @Efe,
Most likely the existing frame will be fine, because the normalisation of the factors is by motion type, so as long as the symmetry of the motor placements means that one thruster is not (for example) contributing more yaw rotation than another thruster that contributes yaw they will both still have a factor of 1 for yaw, regardless of their factors for forward and lateral motion.
If you want to understand more about the thrust factors I’d suggest you start from this comment 