Hi @Nolan, welcome to the forum 
Are you running an autopilot firmware at the same time as you’re trying to access the Navigator hardware with your Python program? They can’t share control of it, so to use direct programmatic control of the Navigator you’ll need to stop the autopilot first.
To do so, you can
- Open the Autopilot Firmware page, enable Pirate Mode, and “stop autopilot”
- Reboot the vehicle computer, and wait for the interface to re-connect
We have occasionally run into an issue where that automatically restarts itself, in which case you might want to “change board” to SITL instead, so it runs a software-only autopilot which then avoids trying to talk to the Navigator.