Hi @niklas_diver, apologies on the delay in getting to this.
That’s quite unusual, and unexpected. Assuming you’re using our Companion software, are you able to see Pixhawk as a Detected Device, and mavproxy as one of the Active Services on the System page of the Companion web interface?
Out of interest, did you update your macOS version recently? About a week ago we had an issue where MacOS 12.2 seemingly caused some issues with UDP communication.